dendritic cells

[Nature Communications] Researchers showed, by using 16 different stimuli in vitro, that activated dendritic cells in human blood were phenotypically and functionally dichotomous, and pure cultures of type 2 conventional dendritic cells acquired these states upon appropriate stimuli.

[Stem Cell Research & Therapy] Researchers evaluated the therapeutic potential of MSCs isolated from menstrual blood as ready-to-use allo-MSCs in multiple sclerosis by application in its animal model experimental autoimmune encephalomyelitis.

[Nature Communications] Researchers showed, using a genome-wide CRISPR knockout screen, that UBL3 was a necessary component of ubiquitination-mediated trafficking of major histocompatibility complex class II and CD86 in mice and in humans.

[Cell Reports] Scientists revealed that the abrogation of tolerogenic functions during an acute immunogenic maturation depended on an ablation of the tolerogenic conventional dendritic cell (cDC) population, resulting in a dynamic remodeling of the cDC functional landscape.

[Nature Nanotechnology] Researchers described a genetically engineered cell membrane nanovesicle that integrated antigen self-presentation and immunosuppression reversal for cancer immunotherapy.

[Nature Communications] Researchers showed, using a genome-wide CRISPR knockout screen, that UBL3 was a necessary component of ubiquitination-mediated trafficking of major histocompatibility complex class II and CD86 in mice and in humans.