chronic inflammation

[Bone Research] Scientists identified TNF-α and S100A8/A9 proteins as key regulators that control the inflammatory osteoclast precursor response during chronic inflammation.

[PLoS Pathogens] The authors investigated the impact of monocytes, NK cells, and CD8+ T cells in primary HTLV-1 infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type or to the HTLV-1p12KO mutant.

[Seminars in Cancer Biology] Investigators summarize the recent progress in our understanding of the functional roles of RNA-binding proteins (RBPs) in several types of immune responses, and the involvement of RBP dysregulation in the pathogenesis of immune diseases and cancer, and discuss possible therapeutic strategies against cancer by targeting RBPs, coupled with immunotherapy.

[Liver International] Scientists summarize the current literature on the impact of hepatitis D virus (HDV) in HCC development and discuss the potential interplay between hepatitis B, HDV and neighboring liver tissue in liver carcinogenesis.

[British Journal of Cancer] The authors suggest that chronic diseases, including obesity and diabetes, establish the cancer-inducing niche that drives the undifferentiated/progenitor cells into CSCs, which then develop malignant tumours in vivo.

[Nature Metabolism] Scientists combined an evolutionary perspective with physiological data to propose that IL-6’s context-dependent effects on metabolism reflect its adaptive role for short-term energy allocation.