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cell proliferation

Clinically Relevant CHK1 Inhibitors Abrogate Wild-Type and Y537S Mutant ERα Expression and Proliferation in Luminal Primary and Metastatic Breast Cancer Cells

[Journal of Experimental & Clinical Cancer Research] The authors evaluated if kinases could be new targets for the treatment of luminal primary and metastatic breast cancers.

Overarching Roles of Diacylglycerol Signaling in Cancer Development and Antitumor Immunity

[Science Signaling] Exploiting the wide spectrum of diacylglycerol signals from an integrated perspective could underscore meaningful advances in targeted cancer therapy.

Long Noncoding RNA SH3PXD2A-AS1 Promotes NSCLC Proliferation and Accelerates Cell Cycle Progression by Interacting with DHX9

[Cell Death Discovery] The authors found that SH3PXD2A-AS1 expression in NSCLC tissues was upregulated compared with that in normal lung tissues in The Cancer Genome Atlas database by using the GEPIA website.

OCT1-Target Neural Gene PFN2 Promotes Tumor Growth in Androgen Receptor-Negative Prostate Cancer

[Scientific Reports] Scientists performed chromatin immunoprecipitation sequencing in patient-derived castration-resistant androgen receptor-negative prostate cancer cells to identify genes that are regulated by OCT1.

Pancreatic Ductal Adenocarcinoma Cells Employ Integrin α6β4 to Form Hemidesmosomes and Regulate Cell Proliferation

[Matrix Biology] To identify the integrin adhesion systems that operate in PDAC, investigators analyzed a range of pancreatic ductal epithelial cell models using 2D, 3D and organoid culture systems.

Identification of Distinct Slow Mode of Reversible Adaptation of Pancreatic Ductal Adenocarcinoma to the Prolonged Acidic pH Microenvironment

[Journal of Experimental & Clinical Cancer Research] PDAC cells used a distinct and lengthy process of reversible adaptive plasticity centered on the early fast and later slow mitochondrial network dynamics and metabolic adjustment to microenvironmental acidification..

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