cardiac fibroblasts

[Acta Pharmacologica Sinica] Neonatal rat cardiomyocytes and cardiac fibroblasts were used to validate the protective effects of 6-gingerol in response to phenylephrine and transforming growth factor-β challenge.

[Nature Communications] Mechanistic studies revealed roles of eosinophil IL4 and cationic protein mEar1 in blocking H2O2- and hypoxia-induced mouse and human cardiomyocyte death, TGF-β-induced cardiac fibroblast Smad2/3 activation, and TNF-α-induced neutrophil adhesion on the heart endothelial cell monolayer.

[Circulation] The role of cardiac IgE receptor (FcεR1) signaling in pathological cardiac remodeling was explored in vivo by FcεR1 genetic depletion, anti-IgE antibodies, and bone-marrow transplantation. The roles of immunoglobulin E (IgE)-FcεR1 pathway were further evaluated in vitro in primary cultured rat cardiomyocytes and cardiac fibroblasts.

[Cell Death & Disease] β-adrenergic receptor (β-AR) overactivation induced inflammasome activation in both the cardiomyocytes and cardiac fibroblasts of mice hearts following a subcutaneous injection of isoproterenol, a selective agonist of β-AR.

[Circulation Research] In rat and mouse models of ischemic heart failure, investigators showed that miR-30d gain of function improves cardiac function, decreases myocardial fibrosis, and attenuates cardiomyocyte apoptosis.

[Advanced Healthcare Materials] The authors briefly survey cell sources and delivery strategies, along with biomaterials and their processing techniques, developed for myocardial infarction treatment. Key issues and challenges, as well as recommendations for future research, are also discussed.