cardiac fibroblasts

[Molecular Therapy-Nucleic Acids] Scientists developed a transgenic mouse line overexpressing the circular RNA circNlgn and showed that circNlgn was a mediator of Doxorubicin-induced cardio-fibrosis.

[Basic Research in Cardiology] Researchers established an in vitro iPSC model of anthracycline-induced cardiotoxicity (ACT) from patients with an aggressive form of B-cell lymphoma and examined whether doxorubicin-treated ACT-iPSC cardiomyocytes could recapitulate the clinical features exhibited by patients.

[Stem Cell Reviews and Reports] Researchers reported human urine cells could be converted into CM-like cells from different donors and the related chromatin accessibility dynamics by assay for transposase accessible chromatin-seq.

[Bmb Reports] Scientists investigated whether tactical control of muscleblind-like 1 (MBNL1) activity could alter myofibroblast activity and fibrotic outcomes.

[Molecular and Cellular Biochemistry] Scientists showed that cardiac fibroblasts protected cardiomyocytes against myocardial ischemia/reperfusion-induced injury through suppression of pyroptosis.

[Journal of the American Heart Association] The conversion of fibroblasts into induced cardiomyocytes may regenerate myocardial tissue from cardiac scar through in situ cell transdifferentiation. Scientists explored the leveraging of Hippo pathway intermediates to enhance induced cardiomyocyte generation.