breast cancer stem cells

[Pharmacological Research] Investigators explored the effect of sinomenine hydrochloride (SH) on breast cancer stem cells (BCSCs) and its mechanism and observed that SH decreased the ratio of CD44+/CD24- BCSCs and the expression of BCSCs-related genes in MCF-7 and MDA-MB-231 cells.

[Dalton Transactions] Investigators reported a biologically stable copper(II) complex based on the active site of Type I copper electron transport proteins.

[Frontiers in Oncology] The authors describe the potential targets that may be used for breast cancer treatment from the aspects of PI3K/AKT signaling pathway, DDR, angiogenesis, the cell cycle, breast cancer stem cells, etc

[Nature Communications] Researchers demonstrated that the breast CSC secretome autonomously compressed the stem cell population.

[Glycoconjugate Journal] The authors indicate that GD3 synthase contributes to gefitinib resistance in epidermal growth factor receptor-positive breast cancer cells, and is a potentially useful therapeutic target in drug-resistant breast cancers.

[Oncogene] Researchers demonstrated a novel mechanism whereby Wnt/β-catenin signaling pathway was regulated by different kinases in response to metabolic requirement of CSCs, and suggest that SIK2 inhibition may potentially be a strategy for eliminating breast CSCs.