astrocytes

[Communications Biology] The authors showed that endothelial-induced astrocytes had upregulated expression of A1 astrocytic genes and exhibited a distinctive ECM remodeling profile.

[Neurobiology of Disease] Current evidence points towards infiltrating monocytes as also playing a role in neuron death. Further characterization of the successive molecular changes in both the resident and peripheral immune cells invading the Parkinson's disease brain will provide targets for disease modification.

[Neuron] Researchers reported that mouse and patient induced pluripotent stem cells-derived astrocytes with diverse ALS/frontotemporal dementia (FTD)-linked mutations (SOD1, TARDBP, and C9ORF72) displayed elevated levels of intracellular inorganic polyphosphate.

[Developmental Neuroscience] The authors showed that localized astrogenesis played an important role in gyri formation in the gyrencephalic cerebral cortex.

[Biotechnology and Bioengineering] Scientists investigated whether Schwann cells could be involved in the disease pathogenesis, and developed a tissue-engineered 3D in vitro model that combined motor neurons cocultured with astrocytes.

[Metabolic Brain Disease] The authors review the mechanisms by which a reactive gliosis can induce or contribute to the development and progression of Alzheimer’s disease.