astrocytes

[Molecular Cell] The authors demonstrated that the entire miR-10b-hosting HOXD locus was activated in glioma via the cis-acting mechanism involving 3D chromatin reorganization and CTCF-cohesin-mediated looping.

[Neuro-Oncology] Scientists used single-cell RNA-sequencing to analyze new and recurrent glioblastoma, and the nearby subventricular zone. They found four glioblastoma neural lineages were present in new and recurrent glioblastoma with an enrichment of the cancer mesenchymal lineage, immune cells, and reactive astrocytes in early recurrences.

[Nature Communications] The authors investigated if focal ablation of astrocytes were sufficient to disrupt the blood-brain barrier in mice. Targeted two-photon chemical apoptotic ablation of astrocytes induced a plasticity response whereby surrounding astrocytes extended processes to cover vascular vacancies.

[Neuron] To improve understanding of transcriptomic heterogeneity in glia during Alzheimer’s disease (AD), the authors used single-nuclei RNA sequencing to characterize astrocytes and oligodendrocytes from apolipoprotein Ɛ2/3 human AD and age- and genotype-matched non-symptomatic brains.

[Neuroscience and Biobehavioral Reviews] The authors summarize current knowledge on the impact of astrocyte and microglia activity on behavioral outcomes, with a specific focus on brain areas relevant to higher cognitive control, reward-seeking, and circadian regulation.

[Molecular Psychiatry] Scientists combined stem cell culturing with transplantation techniques to determine disease-specific properties inherent to autism spectrum disorder astrocytes.