asthma

[Kaohsiung Journal of Medical Sciences] Scientists deciphered the role of the lncRNA antisense noncoding RNA in the INK4 locus in airway smooth muscle cell proliferation, migration and extracellular matrix deposition.

[Science Translational Medicine] In human bronchial epithelial cells, phosphoinositide 3-kinase γ (PI3Kγ) mimetic peptide induced unexpected cyclic adenosine monophosphate and protein kinase A elevations restricted to the vicinity of the cystic fibrosis transmembrane conductance regulator (CFTR), the ion channel controlling mucus hydration that is mutated in CF.

[Proceedings of the National Academy of Sciences of the United States of America] To investigate viral spread, primary human airway epithelial cell cultures were infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and host–virus interactions were examined via electron microscopy, immunohistochemistry, RNA in situ hybridization, and gene expression analyses.

[European Respiratory Review] The authors discuss the molecular and immunological mechanisms involved in physical barrier disruption induced by major airborne pollutants and outline their implications in the pathogenesis of asthma and COPD.

[Science Immunology] Using a mouse model of chronic allergen exposure followed by an allergen-free rest period, scientists characterized a subpopulation of CD4+ T cells that secreted IL-9 as an obligate effector cytokine.

[Inflammation] Investigators focused on how miR-98-5p functioned in the proliferation and migration of human airway smooth muscle cells treated with interleukin-13 (IL-13).