YAP

[Cell Death Discovery] TGF-β from tumor-associated macrophages activated RAD18 in triple-negative breast cancer to enhance tumor stemness, forming a positive feedback loop. Inhibition of YAP or TGF-β broke this loop and suppressed cancer stemness and proliferation.

[Nature Communications] Investigators showed that the aryl hydrocarbon receptor was important for the termination of the regenerative response and the reacquisition of mature epithelial cell identity post injury in vivo and in organoid cultures in vitro.

[Hepatology] Researchers performed single-cell RNA-sequencing using AKT/NICD-induced mouse intrahepatic cholangiocarcinoma tissues at early, middle, and late stages.

[Cell Death & Disease] Researchers assessed transcriptional diversity in 15 liver cancer patients by single-cell transcriptome analysis and observed that transcriptional diversity of tumor cells was associated with stemness in liver cancer patients.

[Biomacromolecules] Scientists presented two series of fibrous and porous hydrogels and used them as substrates to study the mechanoresponses of bone marrow MSCs to stiffness and fibrous structure.

[Cell Death Discovery] Proliferation capability, osteogenic lineage commitment, senescence-associated secreted phenotype and circadian oscillation of clock genes under osteogenic condition were assessed in bone marrow MSCs from young adult and aged adult mice.