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WJ-MSCs
Mesenchymal Cell News
Characterization of Bone Marrow and Wharton’s Jelly Mesenchymal Stromal Cells Response on Multilayer Braided Silk and Silk/PLCL Scaffolds for Ligament Tissue Engineering
[Polymers] Different scaffold configurations were characterized in terms of morphology and a mechanical response, and their interactions with two types of stem cells and bone marrow MSCs were assessed.
Mesenchymal Cell News
Ethionamide Preconditioning Enhances the Proliferation and Migration of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells
[International Journal of Molecular Sciences] Preconditioning with ethionamide promoted the proliferation of Wharton’s jelly-derived MSCs by activating phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated protein kinase kinase (MEK)/extracellular signal-regulated kinase 1/2 signaling.
Mesenchymal Cell News
Clinical Effects of Intrathecal Administration of Expanded Wharton Jelly Mesenchymal Stromal Cells in Patients with Chronic Complete Spinal Cord Injury: A Randomized Controlled Study
[Cytotherapy] Patients were randomly assigned to receive a single dose of intrathecal ex vivo-expanded Wharton's jelly-MSCs from human umbilical cord or placebo and were then switched to the other arm at six months.
Umbilical & Placental Cell News
Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity
[Journal of Clinical Medicine] Researcchers extensively compared the physiological functions of human Wharton’s jelly-derived mesenchymal stem cells in a xeno-free medium and a medium containing 10% fetal bovine serum.
Mesenchymal Cell News
Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton’s Jelly-Derived Mesenchymal Stem Cells
[International Journal of Molecular Sciences] A proteomic approach was employed to identify specific proteins differentially expressed by wharton's jelly derived-MSCs in comparison to those by neonatal foreskin and adult skin fibroblasts.
Mesenchymal Cell News
Anti-Fibrotic Effect of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells on Skeletal Muscle Cells, Mediated by Secretion of MMP-1
[International Journal of Molecular Sciences] In two–five-month-old mdx mice intravenously injected with 1 × 105 Wharton’s jelly-derived mesenchymal stem cells, fibrosis intensity and accumulation of calcium/necrotic fibers were significantly decreased.