WJ-MSCs

[Tissue Engineering and Regenerative Medicine] The differentiation of Wharton jelly (WJ)-MSCs into Schwann cell-like cells was determined by analyzing Schwann cell-specific markers. The secretion of neurotrophic factors was assessed by the Neuro Discovery antibody array.

[Stem Cell Research & Therapy] Wharton's jelly (WJ)-MSCs were cocultured with or without endometrial stromal cells (ESCs) damaged by mifepristone. TUNEL staining assays, EdU proliferation assays, flow cytometry apoptosis assays, and western blot assays were performed to observe the reparative effect of WJ-MSCs on damaged ESCs.

[Stem Cell Research & Therapy] The clinical efficacy was evaluated based on glycemic control status and β cell function, as well as the daily insulin requirement in diabetic patients after receiving umbilical cord-derived stem cell-transplantation compared to baseline values.

[Cellular and Molecular Neurobiology] Cellular deregulation was assessed by measuring glutathione levels, basal calcium and intracellular calcium response under KCl stimulation, as well as the key parameters of proliferation, glial progenitor marker expression and migration.

[International Journal of Molecular Sciences] Scientists investigated the effectiveness of hyaluronan–methylcellulose hydrogels loaded with Wharton’s Jelly-derived mesenchymal stromal cell in vitro and in a rat coccygeal Intervertebral disc degeneration model.

[Scientific Reports] WJ-MSCs were encapsulated in 3D hydrogels derived from human fibrin or platelet lysate and the oxygen level was adjusted to physiological normoxia (5% O2).