STZ

[Stem Cell Research & Therapy] Scientists investigated whether the combination of melatonin and human umbilical cord mesenchymal stem cells (hUC-MSCs) was superior to hUC-MSCs alone in ameliorating high-fat diet and streptozocin-induced type II diabetes mellitus in a mouse model.

[Cell Reports Medicine] Scientists studied the efficacy of a glucagon-like peptide-1 (GLP-1) and estrogen dual agonist (GLP1-E2) in pancreatic islet protection. GLP1-E2 provided superior protection from insulin-deficient diabetes induced by multiple low-dose streptozotocin and by the Akita mutation in mice than a GLP-1 monoagonist.

[Inflammation Research] Scientists demonstrated the protective role of Insulin-like growth factor 1 (IGF-1) against pancreatic β cell dysfunction and to probe into the underlying mechanisms.

[Cell Death Discovery] Scientists demonstrated that in the liver tissues and Kupffer cells of diabetes mellitus patients and streptozotocin-induced hyperglycemic mice, the endoplasmic reticulum stress-ATF6-CHOP signaling pathway was activated.

[Environmental Science and Pollution Research] Stem cells from rat kidney were separated, and the surface stem cell markers were determined by flow cytometry analysis.

[Cell Death Discovery] Researchers determined the effect and potential mechanism of Heparanase on glomerular endothelial cells phenotype under high-glucose conditions.