PTEN-AKT

[Molecular Biology and Evolution] Scientists showed the molecular evolution of NCK-interacting kinase-related kinase, which confered its function for inhibiting placental cell proliferation.

[Bioengineered] Researchers clarified the role of hydroxysafflor yellow A in inhibiting colorectal cancer in vitro and the underlying mechanisms.

[Molecular Therapy-Nucleic Acids] RNA sequencing, qRT-PCR, and Western blot analysis were used to identify the aberrant expression and signaling of miR-148a-3p within cells, mice, and patients with Alzheimer’s disease (AD). Researchers implicated the miR-148a-3p/p35/PTEN pathway as an essential contributor to tau hyperphosphorylation and feed-forward regulation in AD.

[Cell Death Discovery] Investigators explored the repair effect of human umbilical cord MSCs-derived extracellular vesicles on spinal cord injury.

[Cell Reports] Scientists showed that cerebrovascular endothelial cell-specific deletion of Pten resulted in a dramatic increase in vesicular transcytosis by the reduction of major facilitator superfamily domain-containing 2a, leading to increased transcellular permeability of the blood-brain barrier.

[Stem Cell Reviews and Reports] Researchers investigated the effects of extracellular vehicles secreted by human umbilical cord mesenchymal stem cells on angiogenesis under high glucose conditions in vivo and in vitro and to explore the underlying mechanisms.