PBMCs

[Stem Cell Research] COXPD23 caused by mutations in GTPBP3 gene is a rare mitochondrial disease. The patient-derived PBMCs of a sibling with the compound heterozygous variants in GTPBP3: c.1289G>A; c.545G>A were reprogrammed into iPSC lines using non-integrative Sendai virus.

[Stem Cell Research] Scientists generated an iPSC line from the peripheral blood mononuclear cells of an otosclerosis patient. The cell line exhibited normal morphology, karyotype, and pluripotency marker expression.

[Cell Reports] Researchers identified five Clostridium strains that suppressed immune-mediated NF-κB activation in epithelial cell lines, peripheral blood mononuclear cells, and gut epithelial organoids from healthy human subjects and patients with inflammatory bowel disease.

[Cell Reports] Researchers identified five Clostridium strains that suppressed immune-mediated NF-κB activation in epithelial cell lines, peripheral blood mononuclear cells, and gut epithelial organoids from healthy human subjects and patients with inflammatory bowel disease.

[Cell Death Discovery] Scientists confirmed that LPS significantly enhanced the expression of islet cell autoantigen 69 (ICA69) in wild-type mice, macrophages, and cardiomyocytes.

[Science] Researchers demonstrated mux-seq as a systematic approach to characterize cellular composition, identify transcriptional signatures, and annotate genetic variants associated with systemic lupus erythematosus.