Oct4

[Oncology Reports] Investigators aimed to examine the stemness‑inhibitory effects of dinaciclib in MCF‑7 and HCC‑1806 breast cancer cells.

[Birth Defects Research] The authors review how Oct4 is regulated in pluripotent stem cells, and address some of the gaps in knowledge about regulation of the pluripotency network in neural crest cells.

[Advanced Science] The assembly of self-organizing 3D kidney-like structures was observed. Kidney organoids contain podocytes, proximal tubules, and endothelial cells that form networks of capillary loop-like structures.

[Cell Death Discovery] Researchers performed GEO dataset analysis and identified that claudin1 was a critical regulator of epidermal growth factor receptor tyrosine kinase inhibitors resistance in NSCLC cells.

[Advanced Science] Based on clinical samples, patient-derived cells, and cell lines, it was found that liver cancer cells displayed stem-like characteristics upon glutamine shortage due to maintaining the stemness of tumor initiating cells (TICs) and even promoting transformation of non-TICs into stem-like cells by glutamine starvation.

[Science Advances] Oct4 linker mutant ESCs showed decreased expression of self-renewal genes and increased expression of differentiation genes, resulting in impaired ESC self-renewal and early embryonic development.