MTOR

[Science Advances] Investigators found that HSCs temporally transitioned to depend on thrombopoietin, a key extrinsic factor, from E16.5 onward in the developing liver.

[Cell Death Discovery] A constitutively-active mutant Akt1 restored Akt-mTOR activation but only partially ameliorated GNE-493-induced prostate cancer cell death. Moreover, GNE-493 was still cytotoxic in Akt1/2-silenced primary prostate cancer cells.

[Cell Biology International] OSI-027 dose-dependently reduced colon cancer cell viability through inducing the cell apoptosis and induced the apoptosis of colon cancer cells via upregulation of p53-upregulated modulator of apoptosis (PUMA).

[Frontiers in Molecular Biosciences] In vitro genetic ablation of golgi phosphoprotein 3 (GOLPH3) was performed using small interfering RNA transfection, and a stably overexpressed GOLPH3 colon cancer cell line was constructed using the lentivirus system.

[Cancer Research] Three metastasis-associated circRNAs identified in a previous circRNA-sequencing study were screened and validated in two HCC cohorts. CircRPN2 was downregulated in highly metastatic HCC cell lines and HCC tissues with metastasis.

[Clinical Cancer Research] High 2[18F]fluoro-2-deoxy-d-glucose (FDG) avidity conferred worse recurrence-free survival after HCC resection. Whole transcriptome analysis revealed upregulation of mTOR pathway signals in the FDG-avid tumors, together with higher abundance of associated mutations.