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HUVECs

Rapid Shear Stress-Dependent ENaC Membrane Insertion Is Mediated by the Endothelial Glycocalyx and the Mineralocorticoid Receptor

[Cellular and Molecular Life Sciences] Cultured HUVECs were exposed to laminar or non-laminar shear stres. Epithelial Na+ channel membrane insertion was quantified using Quantum-dot-based immunofluorescence staining and the mechanical properties of the cell surface were probed with the Atomic Force Microscope in vitro and ex vivo in isolated aortae of C57BL/6 and ApoE/LDLR-/- mice.

Protrudin Regulates FAK Activation, Endothelial Cell Migration and Angiogenesis

[Cellular and Molecular Life Sciences] Researchers investigated the role of the endoplasmic reticulum-anchored protein, Protrudin, in endothelial cell protrusion, migration and angiogenesis.

Intratumoral Heterogeneity of MYC Drives Medulloblastoma Metastasis and Angiogenesis

[Neuro-Oncology] The authors established the relevance of interclonal cross-talk between MYC-driven and non-MYC-driven medulloblastoma cells.

Kinetics of LYVE-1-Positive M2-Like Macrophages in Developing and Repairing Dental Pulp In Vivo and Their Pro-Angiogenic Activity In Vitro

[Scientific Reports] Enforced expression of Lyve1 in RAW264.7 cells resulted in increased mRNA expression of matrix metalloproteinase 2 (Mmp2), Mmp9, and VEGF A. Lyve1-expressing macrophages promoted the migration and tube formation of HUVECs.

H2O2-Responsive VEGF/NGF Gene Co-Delivery Nano-System Achieves Stable Vascularization in Ischemic Hindlimbs

[Journal of Nanobiotechnology] VEGF/nerve growth factor (NGF)-nanoparticles (NPs) promoted VEGF and NGF co-expression simultaneously, eliminated excessive H2O2, strengthened reactions between SH-SY5Ys and HUVECs, and finally enhanced migration, tube formation, proliferation and H2O2 damage resistance of HUVECs.

HDAC11 Promotes Both NLRP3/Caspase-1/GSDMD and Caspase-3/GSDME Pathways Causing Pyroptosis via ERG in Vascular Endothelial Cells

[Cell Death Discovery] Researchers investigated the role of histone deacetylase 11 (HDAC11) in vascular endothelial cell pyroptosis and its molecular mechanism.

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