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Cell Therapy News
Extracellular Vesicles Released from Neprilysin Gene-Modified Human Umbilical Cord-Derived Mesenchymal Stem Cell Enhance Therapeutic Effects in an Alzheimer’s Disease Animal Model
[Stem Cells International] Investigators manufactured neprilysin gene-enhanced human umbilical cord-derived MSCs and intravenously transplanted them in Aβ1-42-injected Alzheimer’s disease animal models.
Intestinal Cell News
Enteric Glial Cell Heterogeneity Regulates Intestinal Stem Cell Niches
[Cell Stem Cell] Scientists defined the regulation of enteric glial cells heterogeneity in homeostasis and chronic inflammatory bowel disease.
Neural Cell News
The Polarity Protein Par3 Coordinates Positively Self-Renewal and Negatively Invasiveness in Glioblastoma
[Cell Death & Disease] Researchers studied the role of the Par3 protein (encoded by PARD3) in glioblastoma multiforme (GBM). GBM patient transcriptomic data and patient-derived culture analysis indicated diverse levels of expression of PARD3 across and independent from subtypes
Umbilical & Placental Cell News
Human Umbilical Cord Mesenchymal Stem Cells-Derived Extracellular Vesicles Facilitate the Repair of Spinal Cord Injury via the miR-29b-3p/PTEN/Akt/mTOR Axis
[Cell Death Discovery] Investigators explored the repair effect of human umbilical cord MSCs-derived extracellular vesicles on spinal cord injury.
Neural Cell News
Exposure to Cadmium Induces Neuroinflammation and Impairs Ciliogenesis in hESC-Derived 3D Cerebral Organoids
[Science of the Total Environment] The authors identified that cadmium exposure specifically induced apoptosis in neurons and inhibited the proliferation of neural progenitor cells, but neural differentiation was not significantly affected in cerebral organoids.
Neural Cell News
ISL1 Promoted Tumorigenesis and EMT via Aurora Kinase A-Induced Activation of PI3K/AKT Signaling Pathway in Neuroblastoma
[Cell Death & Disease] Investigators identified Insulin gene enhancer binding protein 1 (ISL1) as an oncogene in neuroblastoma (NB). ISL1 is preferentially upregulated in NB tissues compared with normal tissues.