Bcl-2

[Cell Death & Differentiation] Researchers provided a molecular analysis of chlamydial apoptosis-inhibition in infected human cells and demonstrate that the block of apoptosis occurs during the activation of the effectors of mitochondrial apoptosis, Bak and Bax.

[Cell Death & Differentiation] Researchers provided a molecular analysis of chlamydial apoptosis-inhibition in infected human cells and demonstrate that the block of apoptosis occurs during the activation of the effectors of mitochondrial apoptosis, Bak and Bax.

[Food and Chemical Toxicology] Researchers studied the photosensitization potential and mechanism involved in dermal phototoxicity of 2,4,5,6-tetraaminopyrimidine sulfate exposed to the dark and UVA/UVB/Sunlight by using different in-chemico and mammalian HaCaT cells, as test systems.

[Leukemia] Researchers provide a rationale for the clinical development of fadraciclib in chronic lymphocytic leukemia, either alone or in combination with a Bcl-2 antagonist.

[Cell Death & Disease] Researchers constructed colorectal cancer PDOs and selected the Kruppel-like factor 5 (KLF5) inhibitor ML264 as the research object based on the results of an in vitro drug screening assay.

[Cell Cycle] On-target compounds specific to MCL-1 have demonstrated promising efficacy in preclinical models of breast cancer and show potential to enhance the anti-tumor effect of conventional therapies.