B cells

[iScience] Investigators demonstrated that IP3R-mediated Ca2+ signaling and calcineurin regulated B cell proliferation and survival by activating metabolic reprogramming in response to B cell receptor stimulation.

[Thoracic Cancer] Scientists identified radio-responsive genes and explored the biological function of encoded proteins in NSCLC.

[Nature Reviews Cancer] Drawing insights from autoimmunity, scientists review the molecular phenotypes, architectural contexts, antigen specificities, effector mechanisms and regulatory pathways relevant to tumor-infiltrating B lymphocytes in human cancer.

[Cellular Oncology] Scientists investigated signaling cascades of B cell lymphoma 6 (BCL6) in the CSC compartment of triple negative breast cancers, and the mechanisms that govern its activity, mainly through Notch signaling.

[Nature Cancer] The authors presented the PROSECO prospective observational study on 457 patients with lymphoma that received two or three COVID-19 vaccine doses and showed undetectable humoral responses following two vaccine doses in 52% of patients undergoing active anticancer treatment.

[Signal Transduction and Targeted Therapy] Via an unbiased genome-wide CRISPR/Cas9 screening, scientists identified loss of NOXA, a B-cell lymphoma 2 family protein in B cell malignancies, as a pivotal regulator of resistance to CAR T cell therapy by impairing apoptosis of tumor cells both in vitro and in vivo.