B cells

[Scientific Reports] Researchers elucidated the overall smoking-induced miRNA changes and those specific to chronic obstructive pulmonary disease (COPD).They investigated the downstream effects on regulatory gene expression and the correlation to cellular composition.

[Cancer Cell International] The authors indicated a relationship between synaptosome associated protein 25 (SNAP25) expression and prostate cancer, demonstrating that SNAP25 was a potential prognostic biomarker due to its vital role in immune infiltration.

[Immunity] Scientists assessed affinity and neutralization potency against the Omicron variant of several hundred naturally expressed memory B cell-derived monoclonal IgG antibodies from vaccinated COVID-19-recovered and -naïve individuals.

[Nature Methods] The authors presented receptor-antigen pairing by targeted retroviruses, which combined viral pseudotyping and molecular engineering approaches to enable one-pot library-on-library interaction screens by displaying antigens on the surface of lentiviruses and encoding their identity in the viral genome.

[Science] Researchers developed a framework for the classification of individual cells, and by combining single-cell RNA sequencing data with genotype data, they mapped the genetic effects on gene expression in each of 14 immune cell types and identified 26,597 independent cis–expression quantitative trait loci (eQTLs).

[Cell] Investigators examined antibody and memory B cell responses longitudinally for nine to ten months after primary two-dose SARS-CoV-2 mRNA vaccination and three months after a third dose.