AMPK

[Scientific Reports] Researchers investigated the inhibitory effects and underlying governing mechanism of clitorin in a western diet-induced hepatic steatosis mouse model, and in oleic acid-stimulated HepG2 cells.

[Experimental and Molecular Medicine] Researchers investigated the role of hepatic Sestrin2 in cholestatic liver injury and its underlying mechanisms using in vivo and in vitro approaches.

[Proceedings of the National Academy of Sciences of the United States of America] Glutathione peroxidase 2 (GPx2) loss stimulated malignant progression due to reactive oxygen species/hypoxia inducible factor-α (HIF1α)/VEGFA signaling, causing poor perfusion and hypoxia, which were reversed by GPx2 reexpression or HIF1α inhibition.

[Molecular Medicine Reports] Protein expression was detected by western blotting. Cell Counting Kit‑8 assays were performed to analyze cell viability, and flow cytometry and a TUNEL assay was performed to evaluate cell apoptosis.

[Plant Foods For Human Nutrition] Investigators studied the metabolic effect of resveratrol around the circadian clock in order to determine more accurately the hepatic signaling pathways involved. AML-12 hepatocytes were treated with resveratrol and clock and metabolic markers were measured around the clock.

[Scientific Reports] Researchers investigated the therapeutic efficacy of tofacitinib and metformin on IL-17 and transforming growth factor beta cytokines, skin fibrosis and inflammation in mouse model of systemic sclerosis.