AMPK

[Poxel SA] POXEL SA announced that the FDA has granted Fast Track Designation to PXL770 for the treatment of patients with adrenomyeloneuropathy, the most common form of X-linked adrenoleukodystrophy.

[Cell Death & Disease] Phenotypic and metabolic profiles with associated cellular signaling pathways involved in lipid metabolism were investigated in the mice heart and human cardiomyocytes to establish treatment effect of adiponectin's agonists.

[Acta Pharmacologica Sinica] IMM-H007 attenuated isoprenaline-induced cardiac fibrosis, diastolic dysfunction, α-smooth muscle actin expression, and collagen I deposition in both wild-type and AMP-activated protein kinase α2−/− mice.

[Journal of Experimental & Clinical Cancer Research] The authors provide a mechanistic discussion of autophagy in prostate cancer.

[Diabetologia] Mouse lines that expressed a gain-of-function mutation in the γ1 AMP-activated protein kinase (AMPK) subunit D316a were generated to examine the effects of chronic AMPK stimulation in the whole body, or selectively in the beta cell.

[Scientific Reports] Scientists reported the identification of a novel adenosine monophosphate-activated protein kinase (AMPK) modulator, the indolic derivative IND6, which showed affinity for AMPKα1β1γ1, the primary AMPK isoform in human EA.Hy926 endothelial cells.