AKT

[Cell Death & Disease] In vitro and in vivo experiments suggested that ubiquitin-conjugating enzyme E2T (UBE2T) promoted HCC development including proliferation and metastasis.

[Oncogene] CircKDM4B inhibited migration and tube formation of HUVECs in vitro and angiogenesis in vivo.

[Biophysical Journal] The authors demonstrated that T cells exposed to high-e dose-dependently accumulated [K+]e intracellularly.

[Molecular Cancer Research] Investigators revealed that acidosis could significantly trigger fatty acid synthesis to promote liver tumorigenesis by upregulating SCD1 in a PI3K/AKT activation dependent manner and simultaneously promote SCD1 binding to PPARα.

[Scientific Reports] Scientists explored clinical factors in 332 advanced NSCLC who received EGFR TKI and molecular characteristics through 65 whole exome sequencing of various EGFR TKI responses including; de novo, intermediate response and long-term response.

[Signal Transduction and Targeted Therapy] EPHA2 might contribute to platelet-derived growth subunit A (PDGFA) signaling transduction in combination with platelet-derived growth receptor α (PDGFRA) and mediate the resistance of glioblastoma cells to PDGFRA inhibitor.