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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Methylation of RBM39 by PRMT6 Enhances Resistance to Indisulam in Non-Small Cell Lung Cancer by Promoting Alternative Splicing of Proto-Oncogenes
[PLOS Biology] Scientists demonstrated that hypermethylation of RNA-binding protein 39 (RBM39), a specific target of Indisulam, is closely associated with Indisulam resistance. Protein arginine methyltransferase 6 (PRMT6) methylates RBM39 at R92.
Pelargonidin-3-O-galactoside Alleviates Acute Lung Injury Induced by Klebsiella pneumoniae by Targeting CD38-Mediated Pyroptosis
[Journal of Agricultural and Food Chemistry] Scientists explored the protective effects of pelargonidin-3-O-galactoside on Klebsiella pneumoniae-induced acute lung injury and its underlying mechanisms.
γδ+ T Cell-Derived IL-17A Stimulates Airway Epithelial/Stromal Cells to Secrete G-CSF, Promoting Lung-Specific Pathogenic Siglec-F+ Neutrophil Development in PPE-Induced Emphysema
[Cellular & Molecular Immunology] Scientists identified a distinct population of lung-specific pathogenic Siglec-F+ neutrophils in a porcine pancreatic elastase (PPE)-induced mouse model of emphysema.
Pulmonary Hazards of Nanoplastic Particles: A Study Using Polystyrene in In Vitro Models of the Alveolar and Bronchial Epithelium
[Journal of Nanobiotechnology] Researchers used model polystyrene nanoparticles doped with the fluorescent metal europium to enhance the understanding of nanoparticles hazard and investigates adverse outcomes associated with exposure in human lungs using alveolar and bronchial cell models grown.
Mitomycin Induced the Senescence of Alveolar Epithelial Cells by Targeting Peroxiredoxin I
[Biochemical Pharmacology] A method of small-molecule ligand–protein interaction by pulldown/mass spectrometry identifies peroxiredoxin I (Prdx I) as the target of mitomycin-induced alveolar epithelial cell senescence, and mitomycin significantly inhibits the peroxidase activity of Prdx I.
Alveolar Epithelial and Vascular CXCR2 Mediates Transcytosis of CXCL1 in Inflamed Lungs
[Nature Communications] Using conditional endothelial and epithelial CXCR2 knockout mice, scientists demonstrated that selective CXCR2 deletion in either compartment impairs neutrophil recruitment into the lung during bacterial pneumonia and reduces bacterial clearance.
RNF20 Links the DNA Damage Response and Metabolic Rewiring in Lung Cancer through HIF1α
[Nature Communications] Investigators showed that an RNF20-HIF1α axis links the DNA damage response and metabolic reprogramming in lung cancer.
Molecular Determinants of Sotorasib Clinical Efficacy in KRASG12C-Mutated Non-Small-Cell Lung Cancer
[Nature Medicine] The authors reported one of the largest integrated analyses to date of sotorasib clinical efficacy biomarkers from the Phase II CodeBreaK 100 and Phase III CodeBreaK 200 studies.
ANT1 Deficiency Impairs Macrophage Metabolism and Migration, Protecting against Emphysema in COPD
[American Journal of Respiratory Cell and Molecular Biology] Investigators demonstrated that human alveolar macrophages from patients with moderate COPD have reduced ANT1 expression while macrophages from very severe COPD have elevated ANT1 compared to normal control subjects.
Expression of Membrane Targets for Therapeutics in RET-Positive Non–Small Cell Lung Cancer
[JAMA] In this cohort study of 93 RET+ NSCLC samples and 112 RET wild-type controls, mesenchymal epithelial transition factor receptor immunohistochemistry expression was significantly enriched in RET+ NSCLC.
ITIH4 Attenuates Acute Lung Injury by Fe-Containing Particulate Matter in Mice via Hippo Pathway in Type II Alveolar Epithelial Cells
[Respiratory Research] Scientists investigated the effects of recombinant inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) against acute lung injury in C57BL/6JNarl and B6.Sftpc-CreERT2;Ai14(RCL-tdT)-D mice exposed to Fe-containing particulate matter.
Epithelial Damage and Aging: The Perfect Storm
[Thorax] The authors highlight how, with increasing age, the alveolar epithelium becomes vulnerable to exogenous insults.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
