Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Parenchymal and Inflammatory Responses to Ozone Exposure in the Aging Healthy and Surfactant Protein C Mutant Lung
[American Journal of Physiology-Lung Cellular and Molecular Physiology] Flow cytometric analysis revealed increases in mononuclear myeloid abundance in aged SP-C mutant lungs, paired with a contraction in CD8+ expressing cells.
Innovent and ASK Pharm Jointly Announce NMPA Approval of Limertinib, a Third-generation EGFR TKI for the Treatment of Lung Cancer
[Innovent Biologics, Inc. (PR Newswire)] Innovent Biologics, Inc. and Jiangsu Aosaikang Pharmaceutical Co. Ltd. jointly announced that China's National Medical Products Administration (NMPA) has approved the New Drug Application of limertinib for the treatment of adult patients with locally advanced or metastatic EGFR T790M-mutated NSCLC.
Molecular Characterization of EBV-Associated Primary Pulmonary Lymphoepithelial Carcinoma by Multiomics Analysis
[BMC Cancer] The authors explored primary pulmonary lymphoepithelial carcinoma using whole-exome sequencing and RNA-whole-transcriptome sequencing technologies.
A Novel Human Fetal Lung-Derived Alveolar Organoid Model Reveals Mechanisms of Surfactant Protein C Maturation Relevant to Interstitial Lung Disease
[EMBO Journal] Researchers described the development of mature, expandable alveolar type 2 (AT2) organoids derived from human fetal lungs which were phenotypically stable, could differentiate into AT1-like cells, and were genetically manipulable.
Longitudinal Single-Cell Profiles of Lung Regeneration after Viral Infection Reveal Persistent Injury-Associated Cell States
[Cell Stem Cell] Using single-cell transcriptomics combined with lineage tracing of proliferating progenitors, investigators examined mouse lung regeneration after influenza injury, demonstrating an asynchronously phased response across different cellular compartments.
PLAC8 Attenuates Pulmonary Fibrosis and Inhibits Apoptosis of Alveolar Epithelial Cells via Facilitating Autophagy
[Communications Biology] The authors found that PLAC8 was downregulated in the lungs of idopathic pulmonary fibrosis patients, in bleomycin-induced lungs of mice, and in primary murine alveolar epithelial type II cells and human lung epithelial cell A549 cells.
Epithelial Outgrowth through Mesenchymal Rings Drives Alveologenesis
[JCI Insight] To study the cellular dynamics of this critical stage of lung development, scientists used scanned oblique-plane illumination microscopy of living lung slices to observe alveologenesis in real time at high resolution over several days.
Impact of Co-Mutations and Transcriptional Signatures in Non-Small Cell Lung Cancer Patients Treated with Adagrasib in the KRYSTAL-1 Trial
[Clinical Cancer Research] Patients with advanced KRASG12C-mutant NSCLC treated with adagrasib were included in the analysis. Pre-treatment NGS data were collected per protocol.
Human iPSC-Derived Microglial Cells Protect Neurons from Neurodegeneration in Long-Term Cultured Adhesion Brain Organoids
[Communications Biology] The authors developed an adhesion brain organoid (ABO) platform that allowed prolonged culture of brain organoids. the long-term-ABO system contained abundant astrocytes and could support prolonged survival and ramification of microglia.
Long Non-Coding RNA CAR10 Promotes Angiogenesis of Lung Adenocarcinoma by Mediating Nuclear LDHA to Epigenetically Regulate VEGFA/C
[Communications Biology] Investigators showed lncRNA chromatin-associated RNA 10 (CAR10) was upregulated in the tumor tissue of patients with lung adenocarcinoma and enhanced tumor metastasis.
Anti-PD-1 Exacerbates Bleomycin-Induced Lung Injury in Mice via Caspase-3/GSDME-Mediated Pyroptosis
[Cell Death & Disease] Researchers used a mouse model of lung injury induced by bleomycin (BLM) and then administered anti-programmed cell death 1 (aPD-1) antibodies to induce ICI-related lung injury. Compared with the BLM group, the aPD-1 + BLM group presented greater levels of lung inflammation and fibrosis, and decreased lung function.
Neoadjuvant Nivolumab Plus Ipilimumab Versus Chemotherapy in Resectable Lung Cancer
[Journal of Clinical Oncology] Adults with stage IB-IIIA resectable NSCLC received three cycles of nivolumab once every two weeks plus one cycle of ipilimumab or three cycles of chemotherapy followed by surgery.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
