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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
The NcRNA/Wnt Axis in Lung Cancer: Oncogenic Mechanisms, Remarkable Indicators, and Therapeutic Targets
[Journal of Translational Medicine] The authors comprehensively review the regulatory mechanisms related to the functions of ncRNAs and the Wnt/β-catenin pathway in lung cancer.
Novel Selective Strategies Targeting the BCL-2 Family to Enhance Clinical Efficacy in ALK-Rearranged Non-Small Cell Lung Cancer
[Cell Death & Disease] Investigators found that dynamic BH3 profiling presented an excellent predictive capacity to anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors, that would facilitate their use in a clinical setting and complementing the readout of standard diagnostic assays.
RNA m7G Methylation Regulators and Targets Significantly Contribute to Chronic Obstructive Pulmonary Disease
[Scientific Reports] The combined roles of m7G methylation regulators were explored in COPD for the first time by integrated bioinformatic methods.
The Role of HDAC3 in Pulmonary Diseases
[Lung] Investigators systematically examine the structural and functional features of histone deacetylase 3 (HDAC3) and discuss its multifaceted contributions to pulmonary pathologies, including lung injury, pulmonary fibrosis, and lung cancer.
SMSbiotech Receives Green Light for Phase I Clinical Trial in Australia, Targeting COPD
[SMSbiotech ] SMSbiotech has announced a significant milestone in its pursuit of its regenerative medicine technology, securing approval to commence a Phase I clinical trial in Australia.
Nebulized 2-Deoxylated Glucose Analogs Inhibit Respiratory Viral Infection in Advanced In Vitro Airway Models
[Scientific Reports] Researchers investigated the antiviral and anti-inflammatory effect of three 2-deoxylated glucose analogs by utilizing advanced in vitro air-liquid interface airway models.
Therapeutic Strategies to Reverse Cigarette Smoke-Induced Ion Channel and Mucociliary Dysfunction in COPD Airway Epithelial Cells
[American Journal of Physiology-Lung Cellular and Molecular Physiology] The authors investigated whether the ion channel amplifier nesolicaftor rescued cigarette smoke-induced mucociliary and ion channel dysfunction.
DNA Polymerase Delta 2 Activates Cell Cycle in Lung Adenocarcinoma, Leading to High Malignancy and Poor Prognosis
[Annals of Surgical Oncology] Researchers investigated the relationship between polymerase delta 2 expression and tumor malignancy in lung adenocarcinoma cell lines.
o8g-Modified circPLCE1 Inhibits Lung Cancer Progression via Chaperone-Mediated Autophagy
[Molecular Cancer] Investigators identified differentially expressed circRNAs by RNA high-throughput sequencing and then conducted methylated RNA immunoprecipitation, immunofluorescence analysis, crosslinking immunoprecipitation, and actinomycin D assays to explore circPLCE1 8-oxoguanine (o8G) modification.
SOS1 Inhibitor BI-3406 Shows In Vivo Antitumor Activity Akin to Genetic Ablation and Synergizes with a KRASG12D Inhibitor in KRAS LUAD
[Proceedings of The National Academy of Sciences of The United States of America] Scientists evaluated the in vivo therapeutic efficacy and tolerability of BI-3406-mediated pharmacological inhibition of SOS1 in comparison to genetic ablation of this universal Ras-GEF in various KRAS-dependent experimental tumor settings.
SLC4A7 Suppresses Lung Adenocarcinoma Oncogenesis by Reducing Lactate Transport and Protein Lactylation
[International Journal of Oncology] Lactylome analysis, Transwell and wound healing assay, animal experiments were conducted to validate functional regulation mediated by solute carrier 4A7 (SLC4A7) in LUAD.
Hesperetin Induces Apoptosis in Lung Squamous Carcinoma Cells via G2/M Cycle Arrest, Inhibition of the Notch1 Pathway, and Activation of Endoplasmic Reticulum Stress
[International Journal of Molecular Medicine] The authors investigated the anticancer effects of hesperetin (HST) on lung squamous cell carcinoma cells.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
