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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Human Neural Organoid Microphysiological Systems Show the Building Blocks Necessary for Basic Learning and Memory
[Communications Biology] The authors investigated the foundational elements of learning and memory in neural organoids by quantifying immediate early gene expression in response to chemical modulation, input-specific short- and long-term synaptic plasticity, neuronal network dynamics, connectivity.
Mesenchymal Stem Cells Attenuate Diabetic Vascular Complication by Reducing Irregular Extracellular Matrix Production in Human Blood Vessel Organoids
[Lab On A Chip] Researchers developed a co-culture system using a combination of hESC-derived blood vessel organoids and mesenchymal stem cells.
RAG1 Lentiviral Gene Therapy Restores T Cell Development of RAG1-SCID Patient Cells in Artificial Thymic Organoids
[Blood Advances] Researchers showed that artificial thymic organoid cultures efficiently support T cell development from healthy donor hematopoietic stem and progenitor cells derived from umbilical cord blood or mobilized peripheral blood.
Harnessing TGF-β Signaling to Improve Testicular Organoid Development from Dissociated Testicular Cells
[Stem Cell Research & Therapy] The testicular cells were isolated from prepubertal mice, encapsulated within inner core of Matrigel-based core-shell hydrogel droplets hanging from filter inserts, and exposed to the small molecule TGF-β inhibitors, SB431542 or LY2157299.
USP18 Promotes Ferroptosis in Lipopolysaccharide-Induced Human Kidney Organoids by Stabilizing STING1
[Cell Biology and Toxicology] Researchers used a lipopolysaccharide-induced human kidney organoid model to investigate ferroptosis in sepsis-induced acute kidney injury.
Activation of Store-Operated Calcium Entry and Mitochondrial Respiration by Enterovirus 71 Is Essential for Efficient Virus Replication
[mBio] Researchers demonstrated that EV71 infections induce store-operated Ca2+ entry by activating the Ca2+ sensor stromal interaction molecule 1, which subsequently interacts with Orai1, a plasma membrane Ca2+ channel.
Quercetin Alleviates Acute Pancreatitis by Modulating Glycolysis and Mitochondrial Function via PFKFB3 Inhibition
[Cellular and Molecular Life Sciences] Researchers conducted homology analysis of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) protein and identified quercetin as a potential inhibitor through molecular docking.
Thymosin Beta 4 As an Alzheimer Disease Intervention Target Identified Using Human Brain Organoids
[Stem Cell Reports] Investigators developed cerebral organoids from iPSCs with mutations in amyloid precursor protein associated with familial Alzheimer disease and analyzed the dynamic changes of cellular states.
Pathogenic Microbiota Disrupts the Intact Structure of Cerebral Organoids by Altering Energy Metabolism
[Molecular Psychiatry] The authors investigated the impact of different bacterial populations on the biomolecular structures of cerebral organoids at various levels.
Modeling Lipopolysaccharide-Elicited Inflammation Using 3D Mouse Gastric Organoids
[Cell Biology International] By using mouse gastric organoids that were grown from the isolated glands and maintained the cellular compositions, scientists demonstrated various effects of variable lipopolysaccharide concentrations on the glandular epithelial cells.
Pig Taste Cell-Derived Organoids Synthesize Insulin
[Endocrinology] Pig taste organoids were maintained long-term and continued to express taste stem cell markers and taste receptor cell markers.
Mutations in GFAP Alter Early Lineage Commitment of Organoids
[Glia] Researchers used Alexander disease patient-derived induced pluripotent stem cells to explore the impact of mutant glial fibrillary acidic protein (GFAP) during neurodifferentiation.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
