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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Scientists Get to the Heart of Blood Formation
[TheScientist] Researchers tweak heart-forming organoids to produce blood cells, in a process that mimics embryonic development.
Human Liver Organoids Are Susceptible to Plasmodium vivax Infection
[Malaria Journal] Organoids were used as platform to model liver-stage vivax malaria. Hepatic endoderm cells, endothelial progenitor cells and mesenchymal cells were generated from human induced pluripotent stem cells and self-assembled into liver organoids on top of Matrigel layer.
The Biological Macromolecules Constructed Matrigel for Cultured Organoids in Biomedical and Tissue Engineering
[Colloids and Surfaces B-Biointerfaces] The authors discuss the limitations of both natural and synthetic Matrigel, and describe alternative scaffolds that have been employed for organoid cultures.
Patient-Derived Glioblastoma Organoids as Real-Time Avatars for Assessing Responses to Clinical CAR-T Cell Therapy
[Cell Stem Cell] Investigators analyzed six sets of patient-derived glioblastoma organoids treated concurrently with the same autologous CAR-T cell products as patients in our phase I study.
Spatial Transcriptome and Single Nucleus Transcriptome Sequencing Reveals Tetrahydroxy Stilbene Glucoside Promotes Ovarian Organoids Development Through the Vegfa-Ephb2 Pair
[Advanced Science] Plant-derived compounds were screened for in vitro activity upon ovarian organoids derived from feeder-free female germline stem cells. Tetrahydroxy stilbene glucoside was found to promote the development of ovarian organoids.
TRPV4 Stimulates Colonic Afferents through Mucosal Release of ATP and Glutamate
[British Journal of Pharmacology] ATP and glutamate release were measured by bioluminescence assays from human colon organoid cultures and mouse colon.
Human Colonic Organoids for Understanding Early Events of Familial Adenomatous Polyposis Pathogenesis
[Journal of Pathology] Researchers investigated the early events associated with familial adenomatous polyposis (FAP) using the intestinal organoid model in a single-center study using biopsies from nonadenomatous and adenomatous colonic mucosa of FAP patients and from healthy controls
Generation and Long-Term Culture of Human Cerebellar Organoids from Pluripotent Stem Cells
[Nature Protocols] Scientists described their protocol for a human pluripotent stem cell-derived human cerebellar organoid model, which successfully replicated the cellular diversity of the fetal cerebellum along with some of its distinct cytoarchitectural features.
UBA1 Inhibition Sensitizes Cancer Cells to PARP Inhibitors
[Cell Reports Medicine] Researchers employed a genome-wide CRISPR knockout screen and discovered that the depletion of ubiquitin-activating enzyme E1 (UBA1) enhanced sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPi) in homologous recombination-proficient ovarian cancer cells.
Generating Human Neural Diversity with a Multiplexed Morphogen Screen in Organoids
[Cell Stem Cell] The authors developed an arrayed screen of 14 morphogen modulators in human neural organoids cultured for over 70 days.
ICU Patient-on-a-Chip Emulating Orchestration of Mast Cells and Cerebral Organoids in Neuroinflammation
[ICU Patient-on-a-Chip Emulating Orchestration of Mast Cells and Cerebral Organoids in Neuroinflammation] The development of an Intensive Care Unit (ICU) patient-on-a-chip platform to elucidate the effects pf propofol and midazolam on brain tissue was reported.
Modeling Metabolic-Associated Steatohepatitis with Human Pluripotent Stem Cell-Derived Liver Organoids
[Hepatology Communications] Human liver organoids derived from human pluripotent stem cells were treated with oleic acid and TGFβ to mimic the metabolic-associated steatohepatitis progression.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
