Substitution of SERCA2 Cys⁶⁷⁴ Accelerates Aortic Aneurysm by Inducing Endoplasmic Reticulum Stress and Promoting Cell Apoptosis

Cultured aortic smooth muscle cells (SMCs) were used for protein expression, apoptosis analysis and cell function studies. The irreversible oxidation of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) C674 promoted the development of aortic aneurysm by inducing endoplasmic reticulum stress and subsequent SMC apoptosis.