GCN5-Mediated Regulation of Pathological Cardiac Hypertrophy via Activation of the TAK1-JNK/p38 Signaling Pathway

Researchers explored the role of general control nonrepressed protein 5 (GCN5) in the development of pathological cardiac hypertrophy. GCN5 expression was increased in isolated neonatal rat cardiomyocytes and mouse hearts of a hypertrophic mouse model.