Targeting DRD2 by the Antipsychotic Drug, Penfluridol, Retards Growth of Renal Cell Carcinoma via Inducing Stemness Inhibition and Autophagy-Mediated Apoptosis

Researchers uncovered penfluridol suppressed in vitro cell growth and in vivo tumorigenicity of various renal cell carcinoma cell lines and enhanced the Sutent-triggered growth inhibition on clear cell renal cell carcinoma cell lines.