Metabolically Driven Maturation of Human-Induced-Pluripotent-Stem-Cell-Derived Cardiac Microtissues on Microfluidic Chips

The authors showed that suitable combinations of mechanical stimuli and metabolic cues could enhance the maturation of human iPSC-derived cardiomyocytes, and that the maturation-inducing cues had phenotype-dependent effects on the cells’ action-potential morphology and calcium handling.