PI3Kβ Functions As a Protein Kinase to Promote Cellular Protein O-GlcNAcylation and Acetyl-CoA Production for Tumor Growth

Investigators demonstrate that high glucose induces PI3Kβ binding to O-linked β-D-N-acetylglucosamine (O-GlcNAc) transferase (OGT) in glioblastoma cells, dependent on hexokinase 1-mediated OGT Y889 phosphorylation and subsequent p85α recruitment.