YAP1 Is a Key Regulator of EWS::FLI1-Dependent Malignant Transformation upon IGF-1-Mediated Reprogramming of Bone Mesenchymal Stem Cells

Investigators reported that transient exposure to insulin-like growth factor (IGF)-1 concentrations mimicking serum levels during puberty reprogrammed limb-derived mesenchymal cells of EWS::FLI1-mutant mice to stable transformation and tumorigenicity.