A Gremlin 1-Expressing Splenic Niche Cell Population Restrains Chronic Myeloid Leukemia by Antagonizing the BMP Pathway

Scientists reported that induced expression of the secreted protein Gremlin 1 in a mouse model restrained chronic myeloid leukemia (CML) progression and synergized with tyrosine kinase inhibitor treatment, whereas blockade of Gremlin 1 promoted CML development.