KLF6-Mediated Recruitment of the P300 Complex Enhances H3K23su and Cooperatively Upregulates SEMA3C with FOSL2 to Drive 5-FU Resistance in Colon Cancer Cells

Researchers demonstrated that histone 3 lysine 23 succinylation (H3K23su) was a critical epigenetic determinant of 5-fluorouracil (5-FU) resistance in colon cancer cells, exerting its effects through the modulation of critical genes and transcription factors.