Genetic Variation Modulates Susceptibility to Aberrant DNA Hypomethylation and Imprint Deregulation in Naive Pluripotent Stem Cells

Investigators showed that naive PSCs from inbred mouse strains exhibited strain-specific susceptibility to locus-specific deregulation of imprinting marks during reprogramming and upon exposure to a mitogen-activated protein kinase inhibitor, a common approach to maintain naive pluripotency.