Engineered Mesenchymal Stromal Cells with Bispecific Polyvalent Peptides Suppress Excessive Neutrophil Infiltration and Boost Therapy

Scientists engineered MSCs with P-selectin and E-selectin targeting peptides, assembling them into bispecific polyvalent structures using DNA self-assembly technology. This modification allowed engineered MSCs to compete with chemotactic neutrophils for selectin binding sites on endothelial cells.