Terminal Differentiation and Persistence of Effector Regulatory T Cells Essential for Preventing Intestinal Inflammation

Researchers characterized distinct colonic effector Treg cell transcriptional programs. Attenuated T cell receptor (TCR) signaling and acquisition of substantial TCR-independent functionality seemed to facilitate the terminal differentiation of a population of colonic effector Treg cells that were distinguished by stable expression of the immunomodulatory cytokine IL-10.