CREB3L1 Facilitates Pancreatic Tumor Progression and Reprograms Intratumoral Tumor-Associated Macrophages to Shape an Immunotherapy-Resistance Microenvironment

Functionally, researchers confirmed cyclic AMP response element binding protein 3-like protein 1 (CREB3L1) contributing to PDAC malignant progression including growth and metastasis by multiple in vitro and in vivo models.