THBS2⁺ Cancer-Associated Fibroblasts Promote EMT Leading to Oxaliplatin Resistance via COL8A1-Mediated PI3K/AKT Activation in Colorectal Cancer

Together with single-cell RNA sequencing and spatial transcriptomics analyses, scientists identified THBS2 specifically derived from subsets of cancer associated fibroblasts (CAFs), termed THBS2 + CAFs, which could promote oxaliplatin resistance by interacting with malignant cells via the collagen pathway in colorectal cancer.