DCP1A, a MEK Substrate, Regulates the Self-Renewal and Differentiation of Mouse Embryonic Stem Cells

To understand how mitogen-activated extracellular signal-regulated kinase (MEK) regulates pluripotency maintenance, through transcriptomics and proteomics analyses, researchers first demonstrated that MEK regulated gene expression at multiple post-transcriptional steps, including RNA splicing, nucleocytoplasmic transport, degradation, and translation.