FZD5 Controls Intestinal Crypt Homeostasis and Colonic Wnt Surrogate Agonist Response

An epithelial-specific Fzd5 knockout (KO) elicited lethal pan-intestinal crypt and villus loss, whereas an Lgr5+ intestinal stem cell (ISC)-specific Fzd5 KO depleted Lgr5+ ISCs via premature differentiation and repressed Wnt target genes.