Vasculogenic Skin Reprogramming Requires TET-Mediated Gene Demethylation in Fibroblasts for Rescuing Impaired Perfusion in Diabetes

Human dermal fibroblasts responded to Etv2, Foxc2, and Fli1 nanoelectroporation with elevated expression of endothelial genes in vitro, which was linked to increased ten-eleven translocase 1/2/3 (TET) expression.