Maturation and Persistence of CAR T Cells Derived from Human Pluripotent Stem Cells via Chemical Inhibition of G9a/GLP

Using a stroma-free human iPSC-T cell differentiation platform, researchers screened for epigenetic modulators that influenced T cell specification and identified the H3K9-directed histone methyltransferases G9a/GLP as repressors of T cell fate.