Cell-Autonomous IL6ST Activation Suppresses Prostate Cancer Development via STAT3/ARF/p53-Driven Senescence and Confers an Immune-Active Tumor Microenvironment

Scientists constitutively activated interleukin-6 cytokine family signal transducer (IL6ST) signaling in the prostate epithelium of a Pten-deficient prostate cancer mouse model in vivo and examined IL6ST expression in large cohorts of prostate cancer patients.