DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming

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Scientists explored the critical oncogenic pathways controlled by DNAJB1-PRKACA using patient-derived fibrolamellar carcinoma models, engineered systems, and patient samples.
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Abstract