p21 Regulates Wnt-Notch Balance via DREAM/MMB/RB-E2F1 and Maintains Intestinal Stem Cell Homeostasis

Disruption in Wnt-Notch signaling was accompanied by the loss of intestinal stem cell compartment, increase in Bmi1 positive cells, loss of Olfm4/Lgr5 positive cells, and reduced secretory Paneth cells and goblet cells in the intestinal crypts of p21TKO mice.